YTHDC2 and neoplasm: We also constructed a cell-derived xenograft (CDX) model with WT or YTHDC2−/− H1975 cells with or without treatment with GW4869 (exosome biogenesis inhibitor) and found that knockout of YTHDC2 could significantly increase tumor volume and exosome content, and this effect could be reversed by GW4869 (Fig. S1, E–G).