Following subcutaneous implantation of CEWH, macrophages were recruited and continuously proliferated in the M2 phenotype via the interleukin‐6/signal transducer and activator of transcription 3 (IL‐6/STAT3) pathway within the implant scaffolds over several weeks.[15] This continuously modulated the subcutaneous immune microenvironment, thereby promoting long‐lasting HFs regeneration. Here, STAT3 is linked to Hand-foot syndrome.