To further verify whether the synergistic effect of YM101 and Maraviroc is achieved through the modulation of immunosuppressive cells like MDSCs, we specifically depleted macrophages, MDSCs, and Tregs in the EMT‐6 tumor model using CLD‐Lp, anti‐DR5, and anti‐CD25. The gene discussed is TNFRSF10B; the disease is neoplasm.