Patients with low pre-operative ATIII and undergoing on-pump cardiac surgery, especially with deep hypothermic circulatory arrest and or requiring post-operative mechanical circulatory support [ECMO, Impella, etc.] are likely to have continuing or worse ATIII deficiency, likely contributing to HR [45]. This evidence concerns the gene SERPINC1 and hyperinsulinemic hypoglycemia, familial, 4.