To determine whether reduced Anapc13 is responsible for the impaired function of Sf3b1K700Efl/+/CD4Cre Tregs in the prevention of colitis, an adoptive transfer colitis model was used to determine the function of Anapc13 in the impaired function of Sf3b1K700Efl/+/CD4Cre Tregs. The gene discussed is ANAPC13; the disease is colitis.