Although severe colitis was induced by adoptive transfer of naive CD4+ along, the colitis was greatly inhibited by cotransfer of Sf3b1K700Efl/+/CD4Cre Tregs expressing Anapc13 but not GFP alone, indicated by the prevention of weight loss (Fig. 7A), shortening colon (Fig. 7B), tissue damages (Fig. 7C), and reduced IFN-γ but not IL-17 production from CD4+ T cells [see Fig. 7D and fig. The gene discussed is IL17A; the disease is colitis.