Univariable and multivariable competing risk analysis showed that age, race, grade, T stage, N stage, surgery, chemotherapy, CEA, tumor deposits, lymph node metastasis, metastasis to lung, and tumor size (all P < .05) were statistically significant prognostic factors for cause-specific survival in sigmoid colon cancer with liver metastasis patients, with hazard ratios (HRs) ranging from 1.02 to 2.06. The gene discussed is CEACAM5; the disease is metastatic malignant neoplasm in the lymph nodes.