The mRNA expression of CRSP2 was significantly decreased in both ISC (P < 0.0001) and ISC/R (P < 0.0001) CF compared to the control and ISC/R CF exhibited a significant reduction in CRSP2 transcripts than ISC CF (P < 0.0001) (Fig. 3C). The gene discussed is MED14; the disease is cystic fibrosis.