The proteomics analysis revealed a battery of significantly altered mediators secreted by the ischemia challenged CF where Cofilin 1, and HSP90 (exclusively downregulated under ischemia) and CRSP2, HSP27, and IL8 (exclusively upregulated under ischemia) were considered based on their functional role in cardiac tissue and relative abundance. Here, CXCL8 is linked to ischemia.