Single cell genomics revealed that 63 CF were positive for CRSP2 (FC > 2), which constituted 0.2094% of the parent population where 45 cells in the ISC group (71.43% of CRSP2 + population) and the CRSP2 + cells favored the ISC group and were mapped in six clusters based on the expression status of 6821 genes (Fig. 3F and G). The gene discussed is MED14; the disease is cystic fibrosis.