ADSS2 and neurodegenerative disease: In addition to GLOD4, PGG downregulated septin-7, ataxin-2, and adenylosuccinate synthetase isozyme 2 (ADSS), which were linked in earlier studies to neurodegenerative diseases such as AD, Parkinson’s disease, Huntington’s disease, Down’s syndrome, and frontotemporal dementia.6