To elucidate the mechanism by which Glod4 can affect behavioral hallmarks of AD, we first examined whether our findings of downregulated GLOD4 expression in brains of AD patients (Fig. 1A) can be recapitulated in mouse neuroblastoma cells N2a-APPswe carrying a mutated human AβPP transgene. The gene discussed is GLOD4; the disease is Alzheimer disease.