In addition to GLOD4, PGG downregulated septin-7, ataxin-2, and adenylosuccinate synthetase isozyme 2 (ADSS), which were linked in earlier studies to neurodegenerative diseases such as AD, Parkinson’s disease, Huntington’s disease, Down’s syndrome, and frontotemporal dementia.6 This evidence concerns the gene ADSS2 and juvenile Huntington disease.