TRIP10 encodes a cytoskeletal binding protein involved in endocytosis that suppresses glucose uptake in response to insulin signaling (Feng et al., 2010), GPR108 encodes an orphan G-protein-coupled receptor, and SIK1 encodes a salt-inducible kinase with roles in cancer, epilepsy, and myeloid signaling (Darling and Cohen, 2021). This evidence concerns the gene INS and cancer.