Genes monotonically increasing (cluster 3; n = 2676 genes) are highly enriched for pathways involved in infectious disease and RNA stability, translation and metabolism, and moderately enriched for pathways involved in the unfolded protein response, cellular responses to stress, regulation of apoptosis, and DNA repair (e.g., TBX21, BHLHE40, IL12RB2, STAT1, CCND2, CDK4, PRMT1, ICAM1, EZH2,Supplementary file 3). This evidence concerns the gene CDK4 and infectious disease.