Antagonism of GRK6, a member of the G-coupled receptor kinase family associated with insulin secretion and T2D susceptibility (Varney et al., 2022), and PTK6, an oncogenic kinase studied in the context of cancer (Gilic and Tyner, 2020), led to the inhibition of T cell activation in the nM to uM range. This evidence concerns the gene INS and type 2 diabetes mellitus.