The cis-regulatory architecture of CD4+ T cells is enriched for autoimmune disease GWAS variants (Farh et al., 2015; Chen et al., 2016; Soskic et al., 2019; Robertson et al., 2021; Lu et al., 2021; Chandra et al., 2021; Soskic et al., 2022; Mouri et al., 2022), and T cells from autoimmune patients harbor distinct epigenetic and transcriptomic signatures linking dysregulated gene expression with disease pathogenesis. Here, CD4 is linked to Autoimmunity.