IL2 and immunodeficiency disease: The IL2 gene encodes a cytokine with crucial, pleotropic roles in the immune system, and dysregulation of IL-2 and IL-2 receptor signaling leads to immunodeficiency and autoimmune disorders in mice and humans (Cerosaletti et al., 2013; Spolski et al., 2018; Abbas et al., 2018; Joosse et al., 2021).