Notably, a mechanism for cochlear pathogenesis for the inherited deafness mutation Cx26 (V84L) was ascribed to selectively impaired permeability to inositol 1,4,5-trisphosphate (IP3), which led to impaired Ca2+ wave propagation without changes in electrical coupling (Beltramello et al., 2005). Here, GJB2 is linked to deafness.