GJB2 and deafness: In cases where deafness is syndromic, i.e., accompanied by various cutaneous manifestations, aberrant or gain of Cx26 hemichannel function has been proposed to underlie disease pathogenesis, particularly in KID syndrome (García et al., 2015; Gerido et al., 2007; Lee et al., 2009; Sanchez and Verselis, 2014; Stong et al., 2006; Terrinoni et al., 2010).