In N2a cells expressing APPswe with either WT PSEN1 or the familial disease PSEN1 Δ9 mutation, which results in the exclusion of exon 9, the majority of Aβ42 was colocalised to Rab8-marked Golgi-derived vesicles in the late secretory pathway [210]. This evidence concerns the gene PSEN1 and familial disease.