Romagnuolo et al. [83] subsequently showed that PCSK9 could reduce Lp(a) internalization by LDLR using cultured hepatoma cells and function blocking monoclonal antibodies against the LDLR; similar results were found using fibroblasts from FH patients versus healthy control and using primary liver hepatocytes from mice [83,84]. Here, LDLR is linked to hepatocellular carcinoma.