TP53 and non-small cell lung carcinoma: Indeed, H1975 (p53R273H), H1437 (p53R267P), and H1703 (p53G262fs) Onc-p53 cells were significantly more sensitive to proteasome inhibition by BTZ (IC50 values: 7, 8, and 2 nmol/L, respectively) than NSCLC cell lines harboring WT p53, including A549 (IC50: 49 nmol/L) and H460 [IC50: 51 nmol/L; P < 0.05; Fig. 1C (left); Table 1].