Validating the translational potential of BTZ in Onc-p53 NSCLC, BTZ and the BH3-mimetic navitoclax were synergistically cytotoxic in Onc-p53 but not WT p53 NSCLC cells in vitro, and BTZ effectively limited the growth of Onc-p53–expressing NSCLC xenografts when combined with carboplatin and navitoclax in vivo. The gene discussed is CASC3; the disease is non-small cell lung carcinoma.