In Onc-p53 NSCLC cells, we observed BTZ-mediated ATF3, but not ATF4, induction (Fig. 3G and H; Supplementary Fig. S3A–S3C), which heretofore has not been observed after PI treatment in other tumor contexts, such as MM (51). The gene discussed is CASC3; the disease is non-small cell lung carcinoma.