The results suggested that the abnormal activation of Wnt signaling pathway from other cell sources in the CAC tumor microenvironment might provide support for the occurrence of epithelial adenocarcinoma; meanwhile, the stromal cell CD11b expression in the CAC mouse adenocarcinoma region was significantly increased (Figure 2C), suggesting that it may be involved in the above pathological mechanism. This evidence concerns the gene ITGAM and adenocarcinoma.