When measuring IL1RL1 signalling through secreted IL‐8 levels, we observe signalling with IL3395–270 (Figure 1 Panel B; 25 and 50 ng/mL [p < 0.0001]) and IL33OXR (Figure 2 Panel N; p < 0.01) in the presence of the IL1RL1 protective allele for the extracellular variant (rs1041973 [A]) with the asthma risk TIR signalling domain haplotype (rs10192157 [C]). This evidence concerns the gene IL1RL1 and asthma.