Immunocompromised NSG-MHC I/II DKO mice were inoculated with B7-H3+ EpCAM+ HPAF-II human pancreatic cancer xenografts, engrafted with human PBMCs following the formation of palpable tumors, and then dosed weekly with antibodies. The gene discussed is EPCAM; the disease is familial pancreatic carcinoma.