MAPT and early-onset autosomal dominant Alzheimer disease: Studies have demonstrated that the pathogenesis of Alzheimer’s disease is related to abnormal deposition of β-amyloid protein, neurofibrillary tangles (NFTs) caused by tau protein hyperphosphorylation, neuroinflammatory response, mitochondrial dysfunction, and abnormal synaptic transduction function (DeTure and Dickson, 2019).