DNER and head and neck squamous cell carcinoma: Given these differences in expression, we hypothesized that HPV-associated tumors might exhibit a transcriptional reliance on BET proteins by enhancing transcription of viral and host oncogenic drivers, including HPV oncogenes E6 and E7 and/or c-MYC, a BRD4-dependent host oncogene (45), in HPV-positive HNSCC.