In HPV-positive HNSCC, the downregulation of E2F genes by JQ1 is particularly significant, as the HPV oncoproteins E6 and E7 are known to inactivate p53 and Rb, respectively, leading to the activation of E2F transcription factors and cell cycle dysregulation (49) on HPV oncoproteins and cell cycle regulation. The gene discussed is RB1; the disease is head and neck squamous cell carcinoma.