As expected, MUTYH associated with recessive familial adenomatous polyposis, the only two homozygotes of which also carry biallelic MUTYH variants, had the highest allele frequency, followed by VHL, BRCA1, BRCA2, and PALB2 (Supplementary Tables S7, S8). This evidence concerns the gene BRCA1 and Familial adenomatous polyposis.