Circulating neutrophils are recruited to the tumor site by cells of the TME, such as CAFs [that secrete granulocyte-macrophage colony-stimulating factor (GM-CSF), granulocyte colony-stimulating factor (G-CSF), VEGF, and IL-1β], TAMs (IL-6 and IL-8), T lymphocytes (CXCL1, CXCL2, interferon γ, and TNFα)[60]. This evidence concerns the gene CSF2 and neoplasm.