CSF2 and neoplasm: Furthermore, using a different mouse model of iCCA [LSL-KrasG12D; Trp53Flox/Flox; Alb-Cre (KPPC) mouse], it was shown that neoplastic cells can recruit MDSCs via GM-CSF and that administering a blocking monoclonal antibody halts the recruitment of myeloid cells and decreases the growth and spread of the tumor[73].