In another large prospective study (45) based on the UK Biobank cohort, the authors revealed 10 predictors for 473,611 CVD-free participants, namely age, sex, cholesterol and blood pressure medications, cholesterol ratio (total/high-density lipoprotein), systolic blood pressure, previous angina or heart disease, number of medications taken, cystatin C, chest pain, and pack-years of smoking. This evidence concerns the gene CST3 and angina pectoris.