Thus, in the meta-analysis of Qui et al. (10), VEGFR-2 rs2305948 and rs1870377 (both found in exon regions of VEGF receptor-2 and lead to aminoacidic substitutions that reduce the binding affinity of VEGF to VEGF receptor-2), but not rs2071559, were associated with an increased risk of stroke. The gene discussed is KDR; the disease is Stroke.