Supplementary Table3shows the one-sided Spearman’s correlation (controllingfor age, sex and PMI) between the cortical thickness measures derived fromthe topologically corrected nnU-Net-CRUISE gray matter segmentation with thecorresponding medial temporal lobe (MTL) ratings of p-tau pathology andneuronal loss density as the MTL is a region linked to earlyneurodegeneration in Alzheimer’s disease. This evidence concerns the gene MAPT and Alzheimer disease.