CD163-positive macrophages, the primary macrophages found in cerebral aneurysms, express a specific receptor and are triggered by high levels of oxidative stress contributing to cerebral aneurysm wall degeneration and rupture (Frösen et al., 2012; Fabriek et al., 2005; Lamping et al., 2000; Fisslthaler et al., 2000). The gene discussed is CD163; the disease is brain aneurysm.