Based on histopathology studies, 8/22 patients had confirmed adenoma and 3 had a single nodule, but surgery was done prior to CYP11B2 immunohistochemistry (IHC) availability; 10 had 1 dominant nodule and/or multiple adjacent micronodules (9/10 with positive CYP11B2 IHC); and 1 had adrenal nodular hyperplasia (no IHC) and had a positive oral saline test and a positive posture test. This evidence concerns the gene CYP11B2 and adenoma.