IRS1 and psoriasis: Yao et al. found that ADAM23 was highly expressed in psoriasis lesions compared to healthy controls, Xing et al. found that GJB2 was also significantly overexpressed, and Liu et al. discovered three overlapping biomarkers, IRS1, RAI14, and ARH-GEF10, with lower expression levels in psoriasis lesions compared to normal controls [20, 22, 23].