Despite some limitations of our GFAP-Coasy mouse model, we were able to clearly link the absence of the Coasy gene in astroglial lineage, to a neurodevelopmental disorder, that had previously only been observed in a Coasy knock-out zebrafish model (Khatri et al., 2016) and in patients with PCH12 (van Dijk et al., 2018; Mishra et al., 2022). The gene discussed is COASY; the disease is neurodevelopmental disorder.