We observed that the GFAP-Coasy mouse model, obtained by the specific ablation of the Coasy gene in radial glia during brain development and its descendants, such as astrocytes and some cortical neurons, exhibited a neurodevelopmental disorder characterized by the disorganization of the cerebral cortex and cerebellar layers with variable severity of the clinical phenotypes associated with early death or normal life expectancy. Here, COASY is linked to neurodevelopmental disorder.