PANK2 and Neurodegeneration: Variants in PANK2 cause pantothenate kinase-associated neurodegeneration (PKAN) (OMIM: #234200) (Zhou et al., 2001), while mutations in COASY cause COASY Protein-Associated Neurodegeneration (CoPAN) (OMIM: #615643) (Dusi et al., 2014).