This finding was further corroborated by a subsequent study in the European ancestry population by Grover et al. (2021) and observed in the Singapore population by which the variant is present at different frequencies between mild and severe PD subtypes, underscoring SV2C’s potential role in PD risk modulation and disease progression (Deng et al., 2022; Grover et al., 2021). The gene discussed is SV2C; the disease is Parkinson disease.