NFKB1 and neoplasm: The NF-κB canonical pathway begins at the cell membrane, where different stimuli (such as carcinogens, tumor promoters, stress, endotoxin, apoptosis-inducers, infection, reactive oxygen intermediate inducers and cytokines (104) bind to their corresponding receptors, such as the TNF, toll-like receptors and T/B cell receptors (105).