HIF1A and breast carcinoma: Inhibition of the HIF-1 signaling pathway by andrographolide occurs in MDA-MB-231 and T47D breast cancer cells under hypoxic conditions through its targeting of the expression of HIF-1α mRNA and HIF-1α protein levels via processes such as protein translation or degradation, which terminates the proliferation process of these breast cancer cells (123,126,128).