IL6 and human herpesvirus 8 infection: Likewise, IL‐6 secretion is stimulated by HHV‐8 infection in case of multicenteric lesions, and several observations strongly suggest IL‐6 as the key element contributing to the disease process; (1) Following the removal of the enlarged hyperplastic lymph node, there is a reduction in the levels of serum IL‐6, acute phase reactants, gamma globulin, and an improvement in clinical condition.