TNF and Opportunistic infection: AIGA can inhibit IFN‐γ‐STAT‐1 phosphorylation and downregulate the production of its downstream factors (IL‐12 and TNF‐α), causing severe defects in the immune response of Th1 cells, resulting in impaired clearance of intracellular pathogens and susceptibility to severe or disseminated opportunistic infections, with an inferior prognosis.5