Studies have shown that MAC is the most common causative NTM subspecies of bone disseminated NTM infection, mainly as osteolytic lesions, pathological fractures, etc. The possible mechanism is that the balance between osteoclasts and osteoblasts is disrupted due to the blocking and neutralizing effects of AIGA against IFN‐γ,10, 11 and it is elementary to misdiagnose it as bone tuberculosis, metastatic tumors, and multiple myeloma. The gene discussed is IFNG; the disease is plasma cell myeloma.