Following <i>Salmonella</i> infection, the transcriptional responses of type I interferon-related genes, such as <i>IFNB1</i> and <i>ISG15</i>, were inhibited in <i>STING</i>-deficient HepG2 cells.<h4>Conclusions</h4>We successfully constructed a <i>STING</i>-deficient cell line. This evidence concerns the gene IFNB1 and infection.