Nevertheless, the authors’ use of a proximity ligation assay to measure TFAM-TFB2M protein interactions is a novel potential method to interrogate MQC in patients with sepsis, and their findings are supportive of their hypothesis that deranged TFAM localization to the mitochondria (despite higher protein expression) may be another factor that impairs activation of mitochondrial biogenesis.12 However, the study raises further questions about the biological implications of possible TFAM maldistribution that deserve further study. The gene discussed is TFB2M; the disease is Sepsis.