In this issue of CHEST Critical Care, Thon et al11 interrogated the mitochondrial biogenesis program in 75 patients with sepsis by performing a proximity ligation assay to measure the interactions of two proteins, mitochondrial transcription factor A (TFAM) and mitochondrial transcription factor B2 (TF2BM), in situ in PBMCs. Here, TFAM is linked to Sepsis.