HAVCR2 and gastric cancer: The phenotype of circulating NK cells from GC patients differed from that from healthy controls, characterized by a decrease in the number of NK cells expressing activating molecules, including NKp30, NKp46, NKG2D and DNAM-1, and an increase in the number of NK cells expressing the inhibitory molecules KIR3DL1 and TIM-3; these perturbations are significantly associated with cancer progression (54–56).