IL33 and respiratory system disorder: In asthma and other respiratory diseases, IL-33 expression is closely associated with the release of cytokines associated with type 2 inflammation, and overexpression of IL-33 can lead to the development of chronic inflammation and airway remodeling, which can exacerbate the severity of the disease (12), increase respiratory mucus secretion, which can aggravate the symptoms of the disease, and participate in the regulation of the immune homeostasis, which can influence the development and progression of respiratory diseases (13, 14).