A GSVA indicated that elevated TUBA1C expression was correlated with enhanced activity of oncogenic pathways such as DNA repair, E2F targets, G2/M checkpoint, p53 signaling, hypoxia, MYC targets, PI3K/AKT pathway, and oxidative phosphorylation; this further implies that patients with elevated TUBA1C expression exhibit notable DNA damage and cell cycle dysregulation, which alters metabolism within the TME in ccRCC. The gene discussed is TUBA1C; the disease is nonpapillary renal cell carcinoma.