(100) observed that the frequency of IL-6-174 C allele among the PJI patients was significantly higher than that among the APL patients.Meanwhile, they found that the G allele of the TNF-α polymorphism rs361525, IL1RN*2/*2 and IL1RN*1/*2 genotypes were associated with increased susceptibilities to PJI. Here, IL1RN is linked to juvenile polyposis syndrome.