In summary, SNPs located in the genes of IL-1α (rs1800587), IL-1β (rs16944, rs1143627, rs1143634), IL1RN (rs2234663, rs4251961), IL-4 (rs2243248, rs2243250, rs2070874), IL-6 (rs1800795, rs1800796), IL-10 (rs1800871), IL-12B (rs3212227), TLR2 (rs3804099), TNF-α (rs1799964), tPA (rs4646972), CTSG (rs45567233), COX-2 (rs689466), VDR (rs731236, rs2228570, rs7975232, rs1544410), MMP1 (rs1799750, rs1144393), NLRP3 (rs10754558, rs7525979) and Bax (G (-248) A) may play an important role in the development of osteomyelitis. The gene discussed is NLRP3; the disease is osteomyelitis.