Aside from IL, TNF-α, and MBL, polymorphisms in certain genes, including TLRs, osteoprotegerin (OPG), receptor activator of NF-kappaB (RANK), VDR, and granulocyte colony stimulating factor receptor (GCSFR), have been examined to determine their potential correlations with PJI development. Here, TNFRSF11A is linked to juvenile polyposis syndrome.