Current research has amassed increasing evidence suggesting that SNPs in various genes, including IL-1, IL-6, IFN-γ, TNF-α, VDR, tPA, CTSG, COX-2, MMP1, SLC11A1, Bax, NOS2, and NLRP3, may contribute to the development of osteomyelitis. The gene discussed is TNF; the disease is osteomyelitis.