Aside from IL, TNF-α, and MBL, polymorphisms in certain genes, including TLRs, osteoprotegerin (OPG), receptor activator of NF-kappaB (RANK), VDR, and granulocyte colony stimulating factor receptor (GCSFR), have been examined to determine their potential correlations with PJI development. This evidence concerns the gene TNF and juvenile polyposis syndrome.