SNPs located in the genes of IL-1β (rs16944, rs1143634), IL1RN (rs2234663), IL-6 (-174 G/C, A/G nt565), TNF-α (rs361525), MBL-550 G/C, MBL-54 G/A, MBL2 (rs11003125), OPG (rs3102735), RANK + 575 C/T, VDR-T, GCSFR may be involved in the PJI (Figure 1, Table 1). Here, IL1B is linked to juvenile polyposis syndrome.