NFKB1 and colorectal cancer: For example, in colorectal cancer cells, overexpression of BIRC3 can lead to the activation of receptor-interacting serine/threonine protein kinase 2 (RIPK2), which promotes the ubiquitination of IKBKG, thereby inhibiting IKBKG protein expression and enhancing the expression of NF-κB subunits p50 and p65 (97).