BIRC3 and rheumatoid arthritis: As E3 ubiquitin ligase, cellular inhibitor of apoptosis protein 1 (cIAP2), and cellular inhibitor of apoptosis protein 2 (cIAP2) are involved in the proliferation and survival of FLS by regulating TNF receptor signaling and inflammatory cytokine production to influence the immune response to RA, and interacting with apoptosis-related signaling pathways to prevent apoptosis (22).