TBCE and metabolic dysfunction-associated steatohepatitis: Given the association between the functional activity of KCs and the development of pathological states, the inability of KCs to regulate the inflammatory response with precision would result in hepatic chronic inflammation, including NAFLD and NASH, by increasing the expression of proinflammatory factors and genes related to fibrosis and oxidative damage (Dixon et al., 2013; Chen et al., 2020).