Importantly, our organotypic‐associated CAFs express α‐smooth muscle actin (α‐SMA) and vimentin which suggests that these are indeed tumor‐promoting CAFs, and not normal fibroblasts (NCAF), or the type of fibroblasts associated with benign prostate‐hyperplasia (BPH).21, 61, 62. Here, ACTA1 is linked to neoplasm.