This leads to phosphorylation and activation of the key downstream FGFR mediator p‐FRS2α, which in turn activates the intracellular cell cycle cascade ERK1/2, PI3Kinase/AKT, and PLCγ/MAPK signaling leading to cancer progression including in PCa.10, 11, 12. This evidence concerns the gene MAPK3 and posterior cortical atrophy.