In cases where PCa has advanced despite prostatectomy or PCa is primarily metastasized, the patient is typically treated with androgen deprivation therapy (ADT), in which androgen effects are suppressed by inhibiting androgen synthesis indirectly or directly,2 or by blocking their activity using AR inhibitors (ARis) such as enzalutamide and darolutamide.3 The gene discussed is AR; the disease is posterior cortical atrophy.