CD44 and cancer: In fact, it has been reported that in cancer cells, the GCX functions as a mechanosensory organ that senses interstitial flow, and affects the expression of matrix metalloproteinase‐1 (MMP‐1), MMP‐2, CD44, and α3 integrin which regulate cell motility and metastasis induced by interstitial flow.21, 56, 57, 58, 59, 60, 61