In their research, USP53, as a tumor suppressor, inhibited the proliferation and migration of Huh-7 and HCCLM3 cells in vitro, promoting apoptosis by deubiquitinating and stabilizing cytochrome C (a key apoptotic protein) to prolong its active time and restrained the growth of transplanted tumor in vivo. The gene discussed is CYCS; the disease is neoplasm.