REG1B and metabolic syndrome: Reg1b was identified as a key duodenal protein related to specific microbial taxa in the BEED cohort [53], and, in a recent study of metabolic syndrome, REG1B was profoundly induced by the butyrogenic Anaerobutyricum soehngenii [54] Stimulation of Reg1 signaling might hasten epithelial repair and be a target for treating EED, for example via prebiotic or probiotic interventions.