NPC1 and acute myeloid leukemia: Among these, the TOP10 genes with the highest mutation frequencies in AML were IDH, TP53, WT1, IDH1, KRAS, PTPN11, ACACB, APC, NPC1, and QRICH2. IDH, a mutated enzyme in the citric acid cycle, leads to the production of the oncogenic metabolite R-2-hydroxy-glutarate.