FTO and malignant colon neoplasm: The subcellular localization of FTO, which appears to differ between tissue- and/or cell-types, has been suggested to play a role in determining its target preference [34]: for example, FTO is nuclear in HEK293 cells [37], whereas it localizes to both cytoplasm and nucleus in colon cancer cells, where it appears to regulate m6Am in the cytoplasm [27].