Consistent with our findings in HEK293 cells, FTO CLIP-qPCR experiments showed significantly reduced signal for MTA1 transcripts in HCT-116 cells treated with siZBTB48, in comparison with control siNT cells (Fig. 6D), suggesting that ZBTB48 facilitates targeting of FTO to MTA1 transcripts in CRC cells. The gene discussed is MTA1; the disease is colorectal carcinoma.