METTL3 and colorectal carcinoma: Since MTA1 mRNA has been shown to be stabilized by the direct binding of IGF2BP2 in CRC cells [52], we performed RIP-qPCR experiments in HCT-116 cells and observed that IGF2BP2 is bound to MTA1 mRNA and that this binding was significantly increased in ZBTB48-depleted cells, whereas METTL3 knockdown significantly reduced this binding (Additional file 1: Fig. S12C).