SIRT3 are a family of proteins with enzymatic activity, is involved in maintaining mitochondrial integrity, homeostasis, and function and plays an important protective role in cardiovascular health, including myocardial ischemia–reperfusion, cardiac hypertrophy, and even heart failure (Zhang et al. 2023a, b; Wang et al. 2023; Deng et al. 2021). This evidence concerns the gene SIRT3 and heart failure.