UPF1 has been identified as a RBP binding to circRPPH1 influencing tumor process (Xu et al. 2022), and recruited by circLPAR1 to modulating GDF-15 mRNA stability involved in Alzheimer’s disease (Xiong et al. 2023). The gene discussed is UPF1; the disease is early-onset autosomal dominant Alzheimer disease.