Specific circRNAs, such as circ-Fryl, circC3P1, circ_0001679, and circ_0001212, have been linked to protective effects against lung injury in sepsis by targeting miRNA pathways, highlighting their therapeutic potential (Zou et al. 2020; Shen et al. 2022; Jiang et al. 2020). The gene discussed is FRYL; the disease is Sepsis.