Noteworthy contributions of Kindlin-2 to BC pathogenicity include the regulation of HIF-1α-mediated activation of tumor angiogenesis, mitotic spindle assembly through inhibiting histone deacetylase 6, maintenance of α-tubulin acetylation, and stabilization of DNA methyltransferase 1 (DNMT1) [24–26]. The gene discussed is DNMT1; the disease is breast cancer.