Loss of expression of either Kindlin-2, TβRI, or β1-Integrin leads to the inhibition of in vitro and in vivo oncogenic behavior of TNBC cells, highlighting the importance of either member of this protein complex in maintaining the oncogenic behavior of cancer cells; loss of one member of this complex is sufficient for the mitigation of the oncogenic activities of cancer cells. Here, TGFBR1 is linked to cancer.