The downstream signaling effectors specific to either TβRI (phosphorylation of SMAD2/3) or β1-Integrin (cell adhesion and spreading on fibronectin) can be inhibited by simply losing Kindlin-2, emphasizing the specificity of Kindlin-2 in modulating TβRI- and β1-Integrin-mediated regulation of the oncogenic behavior of cancer cells. Here, FERMT2 is linked to cancer.