ZBP1 plays an important role in viral infections by inducing necroptosis and apoptosis that act to restrict viral replication but may also cause tissue damage and result in pathology (Koehler et al, 2017; Kuriakose et al, 2016; Thapa et al, 2016; Upton et al, 2012; Zhang et al, 2020). The gene discussed is ZBP1; the disease is viral infectious disease.