NPM3 and colorectal carcinoma: Nucleoplasmin-3 (NPM3), which we identified as a protein with a similar expression pattern to AGR2 in CRC, is an emerging oncoprotein primarily localised in the nucleus and nucleolus, where it exerts its function in ribosome biogenesis by regulating pre-rRNA synthesis and chromatin remodelling function when bound in a pentameric conformation with NPM110,11.